Directions For LiveLong Nutrition CLA-1000: As a dietary supplement, take 1-2 softgel capsule(s) up to three time daily with meals. Always consult your physician before taking supplements.

Warnings: Keep out of reach of children. Consult your physician before using this dietary supplement. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult your healthcare practitioner before beginning any weight loss program..

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Directions For LiveLong Nutrition Green Tea-50: As a dietary supplement, take 1 capsule 1-3 times daily before meals or as directed by your physician.

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Directions For LiveLong Nutrition Na-R-ALA: As a dietary supplement, take one (1) capsule with each meal.

Warnings: Keep out of reach of children. Consult your healthcare provider before use if you have a medical condition.

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• Increased Energy
• Potent Fat Loss Enhancement
• Cutting Edge Performance

Directions For LiveLong Nutrition Caffeine: As a dietary supplement, take 1 capsule 1-3 times daily or as directed by your physician.

Warnings: Keep Out Of Reach Of Children. Consult your physician before using this dietary supplement. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs. Discontinue use and consult your healthcare professional if dizzienss, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult your healthcare practitioner before beginning any weight loss program.

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Chocamine® is a registered trademark of RFI, LLC.

Patent # 7,048,941

An extract from cocoa, Chocamine can promote many health benefits without the unwanted sugars and fat of chocolate. Chocamine contains theobromine, caffeine, and theophylline, phenylethylamine, tyramine, phenylalanine, tryptophan, and tyrosine. Chocamine has been used for mood enhancement and can also be added to a fat loss program.

• Helps Induce Fat Loss
• Increased Energy
• Stimulates Glucose Uptake

Directions For LiveLong Nutrition Tyramine: As a dietary supplement, take 1-2 capsule(s) before your workout or as directed by your physician.

Warnings: Keep Out Of Reach Of Children. Consult your physician before using this dietary supplement. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs. Discontinue use and consult your healthcare professional if dizzienss, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult your healthcare practitioner before beginning any weight loss program.

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• Thermogenic Fat Loss
• Appetite Suppressant
• Increased Lipolysis

Directions For LiveLong Nutrition Raspberry Ketones: As a dietary supplement, take 1 capsule 1-3 times daily before meals or as directed by your physician.

Warnings: Keep Out Of Reach Of Children. Consult your physician before using this dietary supplement. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult your healthcare practitioner before beginning any weight loss program.

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Pomegranate has been shown to be a good source of antioxicants

Directions For LiveLong Nutrition Pomegranate-500: As a dietary supplement, take 1 capsule 1-2 times daily or as directed by your physician.

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Resveratrol

Directions For LiveLong Nutrition Resveratrol-50: As a dietary supplement, take one (1) capsule with each meal.

Warnings: Keep out of reach of children. Consult your physician before using this dietary supplement. Do not use this product if you are at risk or are being treated for high blood pressure, heart, kidney, thyroid, or psychiatric disease, difficulty in urinating, prostate enlargement, anxiety, depression, seizure disorder, or stroke. Consult your healthcare professional before use if you are taking antidepressants, MAO inhibitors, or any other prescription drugs. Discontinue use and consult your healthcare professional if dizziness, sleeplessness, tremors, nervousness, headache or heart palpitations occur. Consult your healthcare practitioner before beginning any weight loss program.

Life extension

The groups of Howitz and Sinclair reported in 2003 in the journal Nature that resveratrol significantly extends the lifespan of the yeast Saccharomyces cerevisiae.^[3] Later studies conducted by Sinclair showed that resveratrol also prolongs the lifespan of the worm Caenorhabditis elegans and the fruit fly Drosophila melanogaster.^[4] In 2007, a different group of researchers was able to reproduce Sinclair’s results with Caenorhabditis elegans,^[5] but a third group could not achieve consistent increases in lifespan of D. melanogaster or C. elegans.^[6]

In 2006, Italian scientists obtained the first positive result of resveratrol supplementation in a vertebrate. Using a short-lived fish, Nothobranchius furzeri, with a median life span of nine weeks, they found that a maximal dose of resveratrol increased the median lifespan by 56%. Compared with the control fish at nine weeks, that is by the end of the latter’s life, the fish supplemented with resveratrol showed significantly higher general swimming activity and better learning to avoid an unpleasant stimulus. The authors noted a slight increase of mortality in young fish caused by resveratrol and hypothesized that it is its weak toxic action that stimulated the defense mechanisms and resulted in the life span extension.^[7]

Later the same year, Sinclair reported that resveratrol counteracted the detrimental effects of a high-fat diet in mice. The high fat diet was compounded by adding hydrogenated coconut oil to the standard diet; it provided 60% of energy from fat, and the mice on it consumed about 30% more calories than the mice on standard diet. Both the mice fed the standard diet and the high-fat diet plus 22 mg/kg resveratrol had a 30% lower risk of death than the mice on the high-fat diet. Gene expression analysis indicated the addition of resveratrol opposed the alteration of 144 out of 153 gene pathways changed by the high-fat diet. Insulin and glucose levels in mice on the high-fat+resveratrol diet were closer to the mice on standard diet than to the mice on the high-fat diet. However, addition of resveratrol to the high-fat diet did not change the levels of free fatty acids and cholesterol, which were much higher than in the mice on standard diet.^[8] A further study by a group of scientists, which included Sinclair, indicated that resveratrol treatment had a range of beneficial effects in elderly mice but did not increase the longevity of ad libitum–fed mice when started midlife.^[9]

[edit] Cancer prevention

In 1997, Jang reported that topical resveratrol applications prevented skin cancer development in mice treated with a carcinogen.^[10] There have since been dozens of studies of the anti-cancer activity of resveratrol in animal models.^[11] No results of human clinical trials for cancer have been reported.^[12] However, clinical trials to investigate the effects on colon cancer and melanoma (skin cancer) are currently recruiting patients.^[13]

In vitro resveratrol interacts with multiple molecular targets (see the mechanisms of action), and has positive effects on the cells of breast, skin, gastric, colon, esophageal, prostate, and pancreatic cancer, and leukemia.^[11] However, the study of pharmacokinetics of resveratrol in humans concluded that even high doses of resveratrol might be insufficient to achieve resveratrol concentrations required for the systemic prevention of cancer.^[14] This is consistent with the results from the animal cancer models, which indicate that the in vivo effectiveness of resveratrol is limited by its poor systemic bioavailability.^{[12][15] [16]} The strongest evidence of anti-cancer action of resveratrol exists for tumors it can come into direct contact with, such as skin and gastrointestinal tract tumors. For other cancers, the evidence is uncertain, even if massive doses of resveratrol are used.^[12]

Thus, topical application of resveratrol in mice, both before and after the UVB exposure, inhibited the skin damage and decreased skin cancer incidence. However, oral resveratrol was ineffective in treating mice inoculated with melanoma cells. Resveratrol given orally also had no effect on leukemia and lung cancer;^[12][17] however, injected intraperitoneally, 2.5 or 10 mg/kg of resveratrol slowed the growth of metastatic Lewis lung carcinomas in mice.^[12][18] Resveratrol (1 mg/kg orally) reduced the number and size of the esophageal tumors in rats treated with a carcinogen.^[19] In several studies, small doses (0.02–8 mg/kg) of resveratrol, given prophylactically, reduced or prevented the development of intestinal and colon tumors in rats given different carcinogens.^[12]

Resveratrol treatment appeared to prevent the development of mammary tumors in animal models; however, it had no effect on the growth of existing tumors. Paradoxically, treatment of pre-pubertal mice with high doses of resveratrol enhanced formation of tumors. Injected in high doses into mice, resveratrol slowed the growth of neuroblastomas.^[12]

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Foocox-10 & Burning The White Stuff
By Colin O’Malley

Please indulge me in my prefacing of this article with the expression of heartfelt love (yes,I’m over reaching here but its for a good point) I have for uncoupling agents.Using such compounds have proven invaluable in my past cutting endeavors.However,not all of us are willing to run cycles of DNP and furthermore,heavy handed uncouplers tend to have harsh side effects and make dieting all the worse.Aye,DNP and usnic acid mediate their magical fat loss effects directly from the thirteenth plane of Hell.

New compounds that may be used safely at any time clearly should be researched and several compounds have recently come into light.One of the more promising agents is fucoxanthin.

In order to describe the benefits of mitochondrial uncoupling,I will elucidate the role that uncoupling plays in body composition.Energy balance in animals is a metabolic state that exists when total body energy expenditure equals dietary energy intake. Energy expenditure, or thermogenesis, can be subcategorized into groups of obligatory and facultative metabolic processes. Brown adipose tissue (BAT), through the activity of uncoupling protein 1 (UCP1), is responsible for nonshivering thermogenesis, a major component of facultative thermogenesis in newborn humans and in small mammals. UCP1, found in the mitochondrial inner membrane in BAT, uncouples energy substrate oxidation from mitochondrial ATP production and hence results in the loss of potential energy as heat. Mice that do not express UCP1 (UCP1 knockouts) are markedly cold sensitive. The recent identification of four new homologs to UCP1 expressed in BAT, muscle, white adipose tissue, brain, and other tissues has been met by tremendous scientific interest. The hypothesis that the novel UCPs may regulate thermogenesis and/or fatty acid metabolism guides investigations worldwide.

I will illustrate a compound that not only acts as an uncoupler (1) but as a life extension tool via its potent antioxidant capabilities (2) and holds promise as a treatment of cancer(3).It also is regarded as a tool in the war against metabolic Syndrome and has multiple other functions within the body (4).It goes beyond uncoupling with regard to fat loss as it actively supresses fat gain by putting a stopgap,so to speak,in the growth of new fat cells. (5) So we have not only all of these attributes to weigh but another very big plus in fucoxanthin’s column is that fucoxanthin chiefly manipulates UCP1,which bears nearly the sole impact on fat loss out of UCP1,UCP2 and UCP3 (6).

So we have established that fucoxanthin acts chiefly on UCP1 and this is primarily responsible for its application towards improving body composition.However,there is a large problem with fucoxathin,which no one has addressed yet in product formulation or even stack suggestions.This would be subpar oral bioavalability (7).If a product isn’t orally bioavailable,little good will come of its use and thus,we are wasting our time and money.However,this issue can be easily circumvented if fucoxathin is taken with fat,MCT oil (8) and fish oil (9) serve as prime examples but any other form of fat will do.Obviously,if fish oil or MCT oil are not utilized,one should use a a desirable fat source that confers other beneficial properties e.g. Enova,sesamin,CLA,olive oil,flax seed oil,lecithin and so on.

Fucoxathin has several quite synergystic angles to exploit,Sesathin being one of them. PPAR-alpha agonism via Sesathin combined with PPARg antagonism would be great. The perfect combo would be PPAR-alpha agonism with gamma antagonism in adipocytes but gamma agonism in other tissues. This is essentially what SIRT-1 activation does in regards to gamma.

Guanidinopropionic Acid,Green Tea Extract and Salvia miltiorrhiza would also be just about the ideal complimentary choices in addition to Resveratrol.The latter would serve to further activate SIRT-1 while the former compounds in essence potentiate attainable benefits through quite a stunning layout of synergystic activity.

References:
1)
Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues.
Maeda H, Hosokawa M, Sashima T, Funayama K, Miya****a K.

Laboratory of Biofunctional Material Chemistry, Division of Marine Bioscience, Graduate School of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
PMID: 15896707

2)
Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites.
Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miya****a K.
Faculty of Fisheries, Hokkaido University, 3-1-1 Minato, Hakodate 041-8611, Japan.
PMID: 17894451

3)
Antiadult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol.
Ishikawa C, Tafuku S, Kadekaru T, Sawada S, Tomita M, Okudaira T, Nakazato T, Toda T, Uchihara JN, Taira N, Ohshiro K, Yasumoto T, Ohta T, Mori N.

Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
PMID: 18798263

4)
Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
Maeda H, Tsukui T, Sashima T, Hosokawa M, Miya****a K.
Faculty of Fisheries Sciences, Hokkaido University, Hakodate 041-8611, Japan.
PMID: 18296336

5)
Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells.
Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miya****a K.
Faculty of Fisheries Sciences, Hokkaido University, Hakodate, Hokkaido 041-8611, Japan.
PMID: 16786166

6)
UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency.
Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B.
The Wenner-Gren Institute, The Arrhenius Laboratories F3, Stockholm University, SE-106 91 Stockholm, Sweden. jan@metabol.su.se
PMID: 11239487

7)
Low bioavailability of dietary epoxyxanthophylls in humans.
Asai A, Yonekura L, Nagao A.
National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642, Japan.
PMID: 18186952

Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin.
Maeda H, Hosokawa M, Sashima T, Funayama K, Miya****a K.
Faculty of Fisheries Sciences, Hokkaido University, Hokkaido, Japan. hayatosp@fish.hokudai.ac.jp
PMID: 17992001

9)
Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice.
Maeda H, Hosokawa M, Sashima T, Miya****a K.
Faculty of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-8611, Japan.
PMID: 17715888